Polystyrene-Induced Renal Oxidative Damage and Inflammation Mediated by PPARγ, IL-17, and MAPK8IP3 in Mice

Authors

  • Abdallah A Baher College of Animal Science and Technology, Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, PR China
  • Saber Y. Adam College of Animal Science and Technology, Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, PR China
  • Chenhui Li College of Animal Science and Technology, Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, PR China
  • Abdelkareem A. Ahmed Department of Veterinary Biomedical Sciences, Botswana University of Agriculture and Natural Resources, Gaborone P.O. Box 100, Botswana
  • Hao-Yu Liu College of Animal Science and Technology, Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, PR China
  • Widad A. Abdalla College of Animal Science and Technology, Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, PR China
  • Kennedy J. Ogamune Joint International Research Laboratory of Agricultural & Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China
  • Hira Sayed College of Animal Science and Technology, Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, PR China
  • Demin Cai College of Animal Science and Technology, Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, PR China

Abstract

 

 Polystyrene-microplastics (PS-MPs) are pervasive environmental contaminants found in common household items, and their ingestion with dietary intake and water is linked to adverse health effects. Following ingestion, PS-MPs can translocate into the circulatory system and accumulate in tissues including kidney. Twelve 6-week-old male C57BL/6 mice were divided into a control group (n = 6) and a PS-MPs group (n = 6) administered 1 mg/kg/day of PS-MPs via oral gavage. Kidney tissue was subjected to histological analysis and thorough transcriptome profiling to identify dysregulated pathways. Histological examination revealed renal atrophy, hemorrhage, thinning of Bowmen’s capsules, and increased Bowmen’s capsules space in the PS-MPs group. TEM confirmed severe ultrastructural damage, including nuclear deformation, cytoplasmic vacuolization, and mitochondrial cristae disruption. Transcriptome analysis showed significant enrichment in the PPAR, MAPK, and inflammatory response signaling pathways. Key dysregulated genes included PPARG, ACADL, and SCP2 (PPAR pathway); MAPK8IP3, MAPK11, and FGFR1 (MAPK pathway); and LI-17, RELA, and TLR1 (inflammatory response).

 This study aimed to investigate the molecular mechanisms underlying PS-MPs-induced kidney injury in a mouse model, with a focus on transcriptomic changes in inflammatory and oxidative stress pathways. In male C57BL/6 mice, PS-MPs exposure induces significant kidney damage at histological, ultrastructural, and molecular levels, dysregulating genes critical to oxidative stress, inflammation, and identifies PPARγ, IL-17 and MAPK8IP3 as pivotal mediators in PS-MPs-induced nephrotoxicity.

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Published

16-06-2026

How to Cite

Baher, A. A., Adam, S. Y., Li, C., Ahmed, A. A., Liu, H.-Y., Abdalla, W. A., Ogamune, K. J., Sayed, H., & Cai, D. (2026). Polystyrene-Induced Renal Oxidative Damage and Inflammation Mediated by PPARγ, IL-17, and MAPK8IP3 in Mice . 8th International Anatolian Agriculture, Food, Environment and Biology Congress, Sinop/Türkiye, 123–135. from https://www.targid.net/index.php/TURSTEP/article/view/637

Congress

2026: 8th International Anatolian Agriculture, Food, Environment and Biology Congress, Sinop/Türkiye

Section

Proceedings